Teratogenic Toxicity of Ethanol Extract of Mahkota Dewa Fruit Flesh (Phaleria macrocarpa (Scheff.) Boerl)

Mahkota Dewa is known as one of the medicinal plants in Indonesia. It contains bioactive compounds and potentially has pharmacological activity. This study aimed to determine possible toxic effects DewaThe ethanol extract fruit flesh was given rats. Group I (control 0.5% Na-CMC), groups II, III IV a treatment group (Mahkota at doses 100, 500 1000 mg/kg bw, respectively). V control satellite (Na-CMC 0, 5%) VI dose bw., Each were treated on day 6 15 gestational. On 19th getation, rats dissected observed skeletal malformations. The data analyzed using one-way ANOVA followed by post-hoc tukey. results toxicity showed that no fetuses had external fetal appearance, all bone preparations normal. Based study, ethanolic Fruit Flesh did not cause teratogenic effect fetus during organogenesis period 100 bw